Modelling biopharmaceutical manufacture: Design and implementation of SimBiopharma

Production Planning of Biopharmaceutical Manufacture

Multiproduct manufacturing facilities running on a campaign basis are increasingly becoming the norm for biopharmaceuticals, owing to high risks of clinical failure, regulatory pressures and the increasing number of therapeutics in clinical evaluation. The need for such flexible plants and cost-effective manufacture pose significant challenges for planning and scheduling, which are compounded b...

Modelling of the biopharmaceutical drug development pathway and portfolio management

Given the time, cost and risk associated with drug development, biopharmaceutical companies typically need to have a portfolio of drugs in development to be successful. Current pressures of cost and speed to market are driving the need for more effective means of assessing the value and risks of such drug portfolios. This paper presents research to generate a prototype computer tool developed t...

Modelling of Random Geometrical Imperfections and Reliability Calculations for Thin Cylindrical Shell Subjected to Lateral Pressure

It is well known that it is very difficult to manufacture perfect thin cylindrical shell. Initial geometrical imperfections existing in the shell structure is one of the main determining factor for load bearing capacity of thin cylindrical shell under uniform lateral pressure. As these imperfections are random, the strength of same size cylindrical shell will also random and a statistical metho...

DOCTORAL (Ph.D.) DISSERTATION Optimization of manufacture and examination of micropellets based on pharmaceutical technological and biopharmaceutical parameters

Optimization of manufacture and examination of micropellets based on pharmaceutical technological and biopharmaceutical parameters